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BIFUMAX 750mg


Composition:
Each vial of lyophilized powder contains:
Cefuroxime sodium equivalent to ..................... 750 mg Cefuroxime

Each solvent ampoule contains:
Water  for  injection ...................................8ml

Dosage form: Lyophilized powder for injection 

Packaging:  Box of 10 vials

Indications:
- Treatment of lower respiratory tract infections ( including pneumonia), serious skin and skin structure infections, genitourinary tract infections, bone and joint infections, septicemia and meningitis caused by susceptible organisms. 
- Perioperative prophylaxis.

Dosage and Administration: 
IM injection; slow IV injection in 3 – 5 minutes; IV infusion.
* Infections:
- Adult: The usual parenteral adult dosage is 750mg – 1,5g every 8 hours. In severe or complicated infections or bone and joint infections require 1,5g every 8 hours and life – threatening infection or infections caused by less susceptible organisms may require 1,5g every 6 hours.
- Pediatric: 30 – 60 mg/ kg of body weight / day. The dosage can be increased to 100mg/ kg of body weight/ day, 3 – 4 divided doses
- Dosage in Renal Impairment: must be adjustment

Clearance creatinin For Adult
10 – 20 ml/min 750 mg, every 12 hours
<10 ml/min 750 mg/time/day

- Patients on hemodialysis: 750 mg at the end of each dialysis. 
- Patients on peritoneal dialysis and dialysis periodically artery - periodic intravenous dose of 750 mg is usually appropriate, Twice a day

* Meningitis:
- Adult: IV administration of dose 3g every 8 hours
- Pediatric: in children 3 months of age of older, the usual dosage of  IV cefuroxime is 200 – 240 mg/kg/ day given in divided doses every 6 – 8 hours.
- Neotatal: receive IV in a dosage of 100mg/ kg of body weight/ day, can be reduced to 50mg/ kg of body weight/ day.

* Lyme disease:
- Use 1,5g in divided dose. Injected in diference area .

* Perioperative Prophylaxis: 
The usual dosage is 1,5g just prior to surgery, and  in lengthy operations, 750mg of the drug IV or IM every 8 hours.

Notes:
- The solvents are: Sodium chloride 0,9%; Glucose 5%; Glucose 10%; Dextrose –Sodium chloride.
- The stability of reconstituted solutions:
+ The IV solutions are stable in 24 hours at room temperature or 48 hours at refrigerature condition.
+ The infusion solutions (with Sodium chloride 0,9% or Glucose 5%are stable in 24 hours at room temperature or 7 days at refrigerature condition (at 5°C).

Contraindications: Please read carefully the leaflet before using

Storage: Store in tight vial, at cool and dry place, protect from light.

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